Real-world evidence on the economic implications of CGRP inhibitors as preventive treatment of migraine​

Background

Our client, a pharmaceutical company, was experiencing that reimbursement of their innovative, preventive treatment of severe migraine was restricted to a narrow subset of the eligible patient population. Our client suspected that treating a wider range of patients would be associated with an economic net gain for society. To determine if this was the case, they needed a study that demonstrated the value of their preventive medicines from a societal point of view.​

Outcome

We conducted a comprehensive real-world evidence (RWE) study to assess the societal impact of initiating preventive treatment with CGRP inhibitors in patients with chronic and episodic migraines. We collected real-world data in collaboration with two patient communities and two informal patient networks. Our analysis included evaluating socioeconomic benefits, such as increased labour supply, and health economic savings.​

​Our RWE study demonstrated that initiating CGRP inhibitor treatment in Danish patients with chronic and episodic migraine could lead to a total societal gain of 4.4 billion DKK per year, primarily driven by a socioeconomic component of 4,294 million DKK through increased labour supply. Health economic savings that are traditionally considered in health technology assessments, accounted for just 3% of the estimated societal gain.​

​We published our findings in a peer-reviewed manuscript and a white paper. Additionally, the study was presented at three major conferences: the MTIS in London, the Migraine Summit in Copenhagen, and the Health Political Summit in Copenhagen.​

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Private Client